Daily consumption of functional egg increases hemoglobin level of children with anemia

Delima Citra Dewi Gunawan; Ali Agus; Muhammad Fathin Hanif

doi:10.21927/ijnd.2024.12(5).%p

Daily consumption of functional egg increases hemoglobin level of children with anemia

Delima Citra Dewi Gunawan, Ali Agus, Muhammad Fathin Hanif

Abstract

Background: Iron is one of the key elements in optimizing the first 1,000 days of life, including stunting prevention. Eggs are animal proteins that are rich in iron and affordable to all, more economically friendly, compared to other animal protein sources like meat.

Objectives: This study aims to determine the effect of daily consumption of eggs on height and hemoglobin level of anemic children under five in Yogyakarta.

Methods: Double-blind randomized controlled trials were used in the study procedures. The samples included sixteen under-five anemic children, separated into two groups: eight recipients of functional eggs as an intervention group and eight recipients of regular eggs as a placebo group. The intervention was passed during 42 days given continuously1 egg/day in the morning for breakfast.

Results: The results showed that there were 1 stunted child in the treatment group and 2 stunted children in the placebo group The average age of recipients was 38 months in treatment and 33 months in placebo. There was an increase in height and hemoglobin with a difference of 1.3 cm for height and 2.8 gr/dl for hemoglobin in the intervention group after being given treatment for 42 days, whereas in the placebo group there was an increase of 0.5 cm for height and 0. 7 gr/dl for hemoglobin. There was a significant difference in hemoglobin levels after the treatment was given between groups (p=0.010), whereas there was not a difference in height (p=0.328). Meanwhile, within intervention group and the placebo group, there were significant differences in height and hemoglobin before and after being given intervention treatment (p<0.05).

Conclusions: Daily Consumption of Functional eggs for 42 days can significantly increase hemoglobin levels in children with anemia.

Keywords

functional egg; anemia children; hemoglobin;height

References

Nugraheni A, Muniroh M, Nindita Y, Wahyudi F, Hariyana B. Association Between Stunting and Anemia Among Toddlers: Stratified by Characteristic of Family and Immunization Status in Mlonggo District, Jepara Regency. Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal). 2023;12(4):196–206.

2018 Riskesdas. Laporan Riskesdas 2018 Nasional.pdf. Lembaga Penerbit Balitbangkes. 2018.

Bustami B, Suryana S, Junita D, Yunianto AE. Fish-Based Complementary Feeding Practices Increasing Macro and Micro Nutrient Intake And Hemoglobin Levels in Anemia Toddlers. Media Gizi Indonesia. 2023;18(3):175–81.

Rahman MS, Mushfiquee M, Masud MS, Howlader T. Association between malnutrition and anemia in under-five children and women of reproductive age: Evidence from Bangladesh demographic and Health Survey 2011. PLoS One. 2019;14(7):1–18.

Hurrell R, Egli I. Iron bioavailability and dietary reference values. American Journal Clinic Nutrition. 2010 May;91(5):1461S-1467S.

Anderson GJ, Mclaren GD. Nutrition and Health Series Editor: Adrianne Bendich Iron Physiology and Pathophysiology in Humans [Internet]. 2012. Available from: http://www.springer.com/series/7659

F D, T A. Factors Affecting Iron Absorption and Mitigation Mechanisms: A review. International Journal of Agricultural Science and Food Technology. 2018 Dec 24;024–30.

Gulec S, Anderson GJ, Collins JF. Mechanistic and regulatory aspects of intestinal iron absorption. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2014 Aug 15;307(4):G397–409.

Omer A, Hailu D, Whiting SJ. Child-Owned Poultry Intervention Effects on Hemoglobin, Anemia, Concurrent Anemia and Stunting, and Morbidity Status of Young Children in Southern Ethiopia: A Cluster Randomized Controlled Community Trial. International Journal Environ Res Public Health. 2023 Apr 5;20(7):5406.

Surai PF, Fisinin VI. 8. Natural multi-nutrient enriched eggs: production and role in health. In: Handbook of eggs in human function. Brill | Wageningen Academic; 2015. p. 133–52.

Browning LC, Cowieson AJ. Vitamin D fortification of eggs for human health. Journal of the Science of Food and Agriculture 2014 May;94(7):1389–96.

Surai PF. Polyphenol compounds in the chicken/animal diet: from the past to the future. Journal of Animal Physiology and Animal Nutrition. 2014 Feb 26;98(1):19–31.

Miranda J, Anton X, Redondo-Valbuena C, Roca-Saavedra P, Rodriguez J, Lamas A, et al. Egg and Egg-Derived Foods: Effects on Human Health and Use as Functional Foods. Nutrients. 2015 Jan 20;7(1):706–29.

Xie C, Elwan HAM, Elnesr SS, Dong XY, Zou XT. Effect of iron glycine chelate supplementation on egg quality and egg iron enrichment in laying hens. Poultry Science. 2019 Dec;98(12):7101–9.

Sarlak S, Tabeidian SA, Toghyani M, Shahraki ADF, Goli M, Habibian M. Effects of Replacing Inorganic with Organic Iron on Performance, Egg Quality, Serum and Egg Yolk Lipids, Antioxidant Status, and Iron Accumulation in Eggs of Laying Hens. Biological Trace Element Research. 2021 May 14;199(5):1986–99.

Kim J, Shin W. How to do random allocation (randomization). Clinic Orthopedic Surgery. 2014;6(1):103–9.

Papanikolaou Y, Fulgoni VL. Increasing egg consumption at breakfast is associated with increased usual nutrient intakes: A modeling analysis using nhanes and the usda child and adult care food program school breakfast guidelines. Nutrients. 2021;13(4).

Cable RG, Steele WR, Melmed RS, Johnson B, Mast AE, Carey PM, et al. The difference between fingerstick and venous hemoglobin and hematocrit varies by sex and iron stores. Transfusion (Paris). 2012 May;52(5):1031–40.

Getawa S, Getaneh Z, Melku M. Hematological Abnormalities and Associated Factors Among Undernourished Under-Five Children Attending University of Gondar Specialized Referral Hospital, Northwest Ethiopia. Journal of Blood Medicine. 2020;11:465–78.

Maharani Saraswati C. Quick guide WHO Anthro Survey Analyser [Internet]. Available from: https://whonutrition.shinyapps.io/anthro

Domellöf M, Campoy C. Iron Requirements of Infants and Toddlers. Article in Journal of Pediatric Gastroenterology and Nutrition [Internet]. 2014; Available from: https://www.researchgate.net/publication/278751634

Cassat JE, Skaar EP. Iron in Infection and Immunity. Cell Host Microbe. 2013 May;13(5):509–19.

Sundararajan S, Rabe H. Prevention of iron deficiency anemia in infants and toddlers. Vol. 89, Pediatric Research. Springer Nature; 2021. p. 63–73.

Zlotkin S. Clinical nutrition: 8. The role of nutrition in the prevention of iron deficiency anemia in infants, children and adolescents. CMAJ. 2003 Jan 7;168(1):59–63.

Ems T, St Lucia K, Huecker MR. Biochemistry, Iron Absorption. 2024.

McKie AT, Barrow D, Latunde-Dada GO, Rolfs A, Sager G, Mudaly E, et al. An Iron-Regulated Ferric Reductase Associated with the Absorption of Dietary Iron. Science (1979). 2001 Mar 2;291(5509):1755–9.

Qian ZM, Tang PL. Mechanisms of iron uptake by mammalian cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1995 Nov;1269(3):205–14.

Waldvogel-Abramowski S, Waeber G, Gassner C, Buser A, Frey BM, Favrat B, et al. Physiology of Iron Metabolism. Transfusion Medicine and Hemotherapy. 2014;41(3):213–21.

Thom CS, Dickson CF, Gell DA, Weiss MJ. Hemoglobin variants: Biochemical properties and clinical correlates. Cold Spring Harb Perspect Med. 2013 Mar;3(3).

Michaelsen KF, Greer FR. Protein needs early in life and long-term health. American Journal Clinic Nutrition. 2014 Mar;99(3):718S-722S.

Dubin S, McKee K, Battish S. Essential amino acid reference profile affects the evaluation of enteral feeding products. Journal of the American Dietetic Association. 1994 Aug;94(8):884–7.

Tome D. Criteria and markers for protein quality assessment – a review. British Journal of Nutrition. 2012 Aug 1;108(S2):S222–9.

De Lange JC. FACTORS CONTRIBUTING TO MALNUTRITION IN CHILDREN 0-60 MONTHS ADMITTED TO HOSPITALS IN THE NORTHERN CAPE. [Bloemfontein]: University of the Free State; 2010.

DOI: http://dx.doi.org/10.21927/ijnd.2024.12(5).%25p