Effectiveness of the combination of ginger-lemongrass beverage and the mother baby-care method on the increase of CD4/CD8 ratio and mental health status in postpartum mother

Diah Widyatun, Mariza Mustika Dewi, Pingkan Amelia Najla

Abstract

Background: The postpartum period requires comprehensive and integrated attention to maternal wellbeing, encompassing both physiological and psychological dimensions. During this critical phase, modulation of the immune system plays an essential role in maintaining the balance of CD4/CD8 ratio, which reflects immune competence, while the prevelance of postpartum mental health problems has been reported to reach up to thirty percent. Natural functional beverages, such as ginger-lemongrass formulations containing  whilst postpartum mental health problem prevalence reaches thirty percent. Ginger-lemongrass beverage containing phenolic compounds at a concentration of 267,37 mgGAE/100g and antioxidant activity with an IC50 value of 20ppm, demonstrates promising immunomodulatory and protective potential.


Objectives: The objective of this study was to analyze the effectiveness of a combined intervention consisting standardized ginger-lemongrass beverage and the MotherBaby-Care method in increasing CD4/CD8 ratio and improving the mental health status of postpartum Mothers.


Methods: This research employed a true experimental design with pretest-posttest control group approach involving forty postpartum mothers who were randomly assigned into four groups : control, ginger-lemongrass beverage only, Motherbaby-Care only and a combination of both interventions. The interventions were administered over a fourteen-day period. Immune status was assessed by measuring the CD4/CD8 ratio using flowcytometry, while mental health status was evaluated using the Self Reporting Questionnaire-20 (SRQ-20).


Results: The result showed that the combination group demonstrated the highest increase in CD4/CD8 ratio (1.748), compared to the MotherBaby-Care (1.328), the ginger-lemongrass (1.206) and control (1.006). Furthermore, the Proportion of mothers without mental health problems increased from seventy percent to ninety percent (p=0.031).


Conclusions:The conclusion of this study is the combination of standardized ginger-lemongrass beverage and the MotherBaby-Care method effectively enhanced immune balance and improved mental health status among postpartum mothers, indocating a superior synergistic effect compared to single interventions.


 

References

Wahyuni Sundari S, Novayanti N, Nur Aulia D. Dukungan Sosial Dan Status Kesehatan Mental Ibu Pascasalin. J Ilm Kesehat Diagnosis. 2023;18:2302–531.

Mahendra, Y. I., Setiawati, D. & N. HUBUNGAN USIA, PARITAS, STATUS EKONOMI, DAN NILAI SPIRITUAL TERHADAP KEJADIAN DEPRESI PADA IBU POSTPARTUM DI RSIA PARAMOUNT TAHUN 2020. J Ilmu Psikol Dan Kesehat. 2020;207–14.

Samosir, F. J., Pane, P. Y., Zebua, J. V. C., Manalu, P., & Dalimunthe SY. KESEHATAN MENTAL IBU MEMENGARUHI PEMBERIAN ASI EKSKLUSIF PADA BAYI: SCOPING REVIEW. Ibnu Sina J Kedokt Dan Kesehat - Fak Kedokt Univ Islam Sumatera Utara. 2025;24(1):111–24.

Anggung M, Prasetyo M, Salabi AS. School Effectiveness: Institutional Benchmarking for Vocational High School Management. J Penelit dan Pengemb Pendidik. 2023;7(3):474–83.

Widyatun D. Wedang Uwuh Meningkatkan Imunitas dan Kualitas Tidur Ibu Nifas [Internet]. Pertama. Winoto D, editor. Purbalingga: Eureka Media Aksara; 2023. 86 p. Available from: https://repository.penerbiteureka.com/media/publications/565570-wedang-uwuh-meningkatkan-imunitas-dan-ku-a42004c2.pdf

Bilgiç FÅž, Bozkurt G. The Effect of Online Infant Care Education and Postpartum Counseling Based on Meleis’s Transition Theory on Mothers’ Self‐Esteem and Infant Health: A Randomized Controlled Trial. Nurs Heal Sci. 2025;27(1):1–13.

Salim, M. A., Simanjuntak, A., Syahrani Arasid, N., Putri, I. M., Suhada, S., & Cahyono D. Strategy to Improve Higher Education Quality through OBE and Benchmarking: Strategi Meningkatkan Kualitas Pendidikan Perguruan Tinggi dengan OBE dan Benchmarking. ADI Pengabdi Kpd Masy. 2025;5(2):140–9.

Saharoy R, Potdukhe A, Wanjari M, Taksande AB. Postpartum Depression and Maternal Care: Exploring the Complex Effects on Mothers and Infants. Cureus. 2023;15(7).

Sauletzhanovna TA, Abdulhussein AH, Ali Mahamda H, Mohammed Al-Akkam EJ, Ali Ahmed B, Rashid Saeed Al-Saadi HA, et al. The Effects of Herbal Treatments on Post-Delivery Pain. J Obstet Gynecol Cancer Res. 2024;9(6):700–6.

Purnomo NAS. Perbedaan Postpartum Fatigue dan Kesehatan Mental Ditinjau dari Metode Kelahiran Ibu. Indones Res J Educ. 2024;4(2):731–9.

Syifani P, Safitri WH, Ramadhani AF, Meggy Novitasari, S.Pd. MP. Penerapan Benchmarking Untuk Meningkatkan Lingkungan Belajar Yang Memotivasi Di Jenjang Sekolah Dasar. J Pendidik. 2025;(January).

Abdullah, Nurudin, Syaefuddin. Membangun Prestasi Sekolah Melalui Benchmarking Teknologi Tepat Guna: Study Kasus Smk Pgri Subang. 2021;3:139–48.

Samosir FJ, Pane PY, Zebua JVC, Manalu P, Dalimunte SY. Kesehatan Mental Ibu Memengaruhi Pemberian Asi Eksklusif Pada Bayi: Scoping Review. J Kedokt dan Kesehatan-Fakultas Kedokt Univ Islam Sumatera Utara. 2025;24(1):111–24.

Ruslan, Aminah S. Implementasi Konsep Benchmarking untuk Meningkatkan Kinerja Institusi Pendidikan. 2025;22(01):90–105.

Tirtawati GA, Kusmiyati K, Damping H, Terok M, Karundeng Y, Bobaya J, et al. The Effect of Herbal Drinks (Moringa, Turmeric, Lemongrass) on Uterine Involution in Post-Partum Women. J Med Chem Sci. 2024;7(6):851–7.

Sundari SW, Novayanti N, Aulia DN. Dukungan Sosial Dan Status Kesehatan Mental Ibu Pascasalin. 2023;18:14–8.

Adnan M, Afifah DN, Anjani G, Susanto H, Noer ER, Widodo S. Giving Ginger and Lemongrass Drink Increase Total Antioxidant Status Level on Adolescent Football Athletes After Physical Exercise. Atlantis Press International BV; 2024. 195–200 p.

Bau R, Wulansari I, Antu MS. Hubungan Body Image Dengan Kesehatan Mental Ibu Post Partum Di Rsud Dr. M.M. Dunda Limboto. 2025;8(7):4819–29.

Diniyati LS, Rahmawati R. Effectiveness of Ginger Herbal Remedies, Ginger Boreh, and Infrared Therapy in Increasing Breast Milk Production. Genius J. 2024;5(2):243–51.

Dzigbor A, Neglo D, Tettey CO, Nsaful F, Addo EO, Ofosu-Pomaa J. The effects of varying ingredients combination and boiling time on total phenolic content, antioxidant activity, and antimicrobial properties of lemongrass-ginger tea. Heliyon. 2024;10(22):e40172.

Nguyen NT, Pengpid S. Proactive approaches to preventing postpartum depression in non-depressive pregnant women: a comprehensive scoping review. Front Glob Women’s Heal. 2025;6(April).

Faradiba, Syarif RA, Anggrayni A, Praditha E, Amalia AR. Evaluation of Antioxidant Activity of Extract Combination of Ginger and Lemongrass. Univers J Pharm Res. 2025;9(6):1–4.

Fitriana L. Implementasi Strategi Benchmarking Dalam Meningkatkan Kinerja Di Lembaga Pendidikan Islam (Studi Multi Kasus di MTsN Aryojeding dan SMPI Al-Azhaar Tulungagung). Prophet J Kaji Keislam. 2023;1(1):33–49.

Mahendra YI, Setiawati D, Najamuddin. Hubungan Usia, Paritas, Status Ekonomi, Dan Nilai Spiritual Terhadap Kejadian Depresi Pada Ibu Postpartum Di Rsia Paramount Tahun 2020. J Ilmu Psikol dan Kesehat. 2023;2(2):207–14.

Magdalena L, Sutrisna, Nuche A, Asri, Aprillia A, Setiawan S. Application of Outcome Based Education in Marketing Management Teaching and Benchmarking Studies. 2025;5(2):150–9.

Authors

Diah Widyatun
diiediahwidy@gmail.com (Primary Contact)
Mariza Mustika Dewi
Pingkan Amelia Najla
Copyright and license info is not available

Article Details