Diagnostic accuracy of TRISS, GAP score, and KTS in predicting survival of traumatic brain injury patients

Akhmad Fauzi, Kuswantoro Rusca Putra, Rinik Eko Kapti

Abstract


Background: Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality worldwide, often resulting in long-term disability or death. The critical period for survival is within the first 6–12 hours after trauma, when secondary brain injury may occur due to hypoxia, hypotension, and systemic complications. To assist clinicians in predicting patient outcomes, several trauma scoring systems have been developed, including the Trauma and Injury Severity Score (TRISS), Glasgow Coma Scale–Age–Systolic Pressure (GAP) Score, and Kampala Trauma Score (KTS).

Objectives: This study aims to evaluate the accuracy of these three scoring systems in predicting survival outcomes in TBI patients

Methods: This research employed a quantitative observational analytic design with a cohort approach involving 212 patients who presented to the Emergency Department (ED) with TBI. Patients were assessed using TRISS, GAP Score, and KTS, and survival status was observed for up to 6 hours. Data were collected by trained ED nurses using standardized procedures, including measurement of Glasgow Coma Scale (GCS), age, respiratory rate, neurological status, systolic blood pressure, and the number of severe injuries. Data analysis included diagnostic tests such as sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and overall accuracy.

Results: The results indicate that GAP Score had the highest sensitivity (99,5%), while GAP score demonstrated the highest specificity (85,7%). The highest PPV was found in TRISS and GAP score (97,1%), whereas KTS had the highest NPV (71,4%). GAP Score achieved the highest accuracy (96,7%), making it the most effective method for predicting TBI patient survival.

Conclusions: The GAP Score is recommended as the most accurate and practical tool for predicting survival in traumatic brain injury patients presenting to the emergency department, especially in clinical environments that require rapid decision-making.


Keywords


GAP score; KTS; survival; traumatic brain injury; TRISS

Full Text:

PDF

References


Faden AI. Neuroprotection and traumatic brain injury: The search continues. Vol. 58, Archives of Neurology. 2020. 1553–1555 p. https://doi.org/10.1001/archneur.58.10.1553

Amare AT, Tesfaye TD, Ali AS, Woelile TA, Birlie TA, Kebede WM, et al. Survival status and predictors of mortality among traumatic brain injury patients in an Ethiopian hospital: A retrospective cohort study. African Journal of Emergency Medicine. 2021;11(4):396–403. https://doi.org/10.1016/j.afjem.2021.06.003

Basak D, Chatterjee S, Attergrim J, Sharma MR, Soni KD, Verma S, et al. Glasgow coma scale compared to other trauma scores in discriminating in-hospital mortality of traumatic brain injury patients admitted to urban Indian hospitals: A multicentre prospective cohort study. Injury. 2023;54(1):93–9. https://doi.org/10.1016/j.injury.2022.09.035

Amakhian AO, Obi-Egbedi-Ejakpovi EB, Morgan E, Adeyekun AA, Abubakar MM. Correlation Between Optic Nerve Sheath Diameter at Initial Head CT and the Rotterdam CT Score. Cureus. 2023;15(7):3–11. https://doi.org/10.7759/cureus.41995

Mulyono D. Perbedaan Glasgow Coma Scale dan Rapid Emergency Medicine Score dalam Memprediksi Outcome Pasien Trauma Kepala di Instalasi Gawat Darurat. Jurnal Kesehatan. 2020;11(2):215. https://doi.org/10.26630/jk.v11i2.1958

Fatimah F, Astilia A, Saputra N. Penggunaan Skoring Trauma Gap Score dan Revised Trauma Score (RTS) Sebagai Prediktor Mortalitas Pasien Cedera Kepala. Health & Medical Journal. 2022;4(2):138–43. https://doi.org/10.33854/heme.v4i2.950

Sudadi. Brain Protection Pada Traumatik Brain Injury. Jurnal Komplikasi Anestesi. 2023;5(1):59–65. https://doi.org/10.22146/jka.v5i1.7323

Yap KE, Islam AA, Ihwan A, Baan JAB, Hamid F. Comparison of Helsinki CT and Rotterdam CT Scoring Systems As Prognostic Factors of Brain Injury. Nusantara Medical Science Journal. 2021;6(1):33–43.https://doi.org/ 10.20956/nmsj.v6i1.13967

Javeed F, Rehman L, Masroor M, Khan M. The Prediction of Outcomes in Patients Admitted With Traumatic Brain Injury Using the Rotterdam Score. Cureus. 2022;14(9):25–30. https://doi.org/10.7759/cureus.29787

Abeytunge K, Miller MR, Cameron S, Stewart TC, Alharfi I, Fraser DD, et al. Development of a Mortality Prediction Tool in Pediatric Severe Traumatic Brain Injury. Neurotrauma Reports. 2021;2(1):115–22. https://doi.org/10.1089/neur.2020.0039

Banin SR, Yueniwati Y, Utami YW. Comparison of Trauma Scoring Ability to Predict Survival Rate in Countries with Low to Middle-Income. International Journal of Science Society. 2020;2(4):194–206. https://doi.org/10.54783/ijsoc.v2i4.204

Smith MJ, Liehr PR. Middle Range Theory for Nursing, Fifth Edition. Middle Range Theory for Nursing, Fifth Edition. Springer Publishing Company. 2023. 1–408 p.

Piñeiro P, Calvo A, Ramos S, Garc S, Power M, Solchaga I, et al. Early Thrombocytopenia at Hospital Admission Predicts Mortality in Patients with Non-Isolated Severe Traumatic Brain Injury. Biomedicines. 2024;12(12):1–14.

https://doi.org/10.3390/biomedicines12122702

J Jojczuk M, Nogalski A, Krakowski P, Prystupa A. Mortality prediction by ‘Life Threat Index’ compared to widely used trauma scoring systems. Annals of Agricultural and Environmental Medicine. 2022;29(2):258–63. https://doi.org/10.26444/aaem/142182

Yang S, Hu P, Kalpakis K, Burdette B, Chen H, Parikh G, et al. Utilizing ultra-early continuous physiologic data to develop automated measures of clinical severity in a traumatic brain injury population. Sci Rep [Internet]. 2024;14(1):7618. https://doi.org/10.1038/s41598-024-57538-5

Merchant AAH, Shaukat N, Ashraf N, Hassan S, Jarrar Z, Abbasi A, et al. Which curve is better? A comparative analysis of trauma scoring systems in a South Asian country. Trauma Surgery Acute Care Open. 2023;8(1):1–7. https://doi.org/10.1136/tsaco-2023-001171

Yousefi MR, Karajizadeh M, Ghasemian M, Paydar S. Comparing NEWS2, TRISS, and RTS in predicting mortality rate in trauma patients based on prehospital data set: a diagnostic study. BMC Emerg Med [Internet]. 2024;24(1). https://doi.org/10.1186/s12873-024-01084-w

Tianda F, Kumboyono K, Suryanto S. Comparison of Sensitivity, Specificity, and Accuracy of ISS, RTS, and TRISS Instruments in Predicting Mortality of Trauma Patients. Journal Health Sains. 2024;5(5):328–46. https://doi.org/10.46799/jhs.v5i5.1274

Dixon J, Comstock G, Whitfield J, Richards D, Burkholder TW, Leifer N, et al. Emergency department management of traumatic brain injuries: A resource tiered review. African Journal of Emergency Medicine. 2020;10(3):159–66. https://doi.org/10.1016/j.afjem.2020.05.006

Moorthy DGSRK, RajeshKaviya K, Prasad RJD. Comparative evaluation of rapid emergency medicine score (REMS) and emergency trauma score (EMTRAS) against traditional trauma scoring systems—namely the injury severity score (ISS), new injury severity score (NISS), revised trauma score (RTS), and trauma. International Journal of Critical Illness and Injury Science. 2025;15(3):101–7. https://doi.org/ 10.4103/ijciis.ijciis_8_25

Albab U, Bahktiar R, Ibrahim A. Perbedaan Nilai Gap Score Terhadap Mortalitas Pasien Cedera Kepala. Jurnal Kedokteran Mulawarman. 2021;8(1):1. https://doi.org/10.30872/j.ked.mulawarman.v8i1.5609

Putri TIYL, Ahsan A, Sugiarto S, Rofiyati W, Triyono HG, Rosyida RW, et al. Perbandingan GAP dan RTS Sebagai Prediktor Perburukan Pasien Cedera Kepala. JI-KES (Jurnal Ilmu Kesehatan). 2021;5(1):84–90. https://doi.org/10.33006/ji-kes.v5i1.220

Mohammed Z, Saleh Y, AbdelSalam EM, Mohammed NBB, El-Bana E, Hirshon JM. Evaluation of the Revised Trauma Score, MGAP, and GAP scoring systems in predicting mortality of adult trauma patients in a low-resource setting. BMC Emergency Medicine [Internet]. 2022;22(1):1–10. https://doi.org/10.1186/s12873-022-00653-1

Farzan N, Foroghi Ghomi SY, Mohammadi AR. A retrospective study on evaluating GAP, MGAP, RTS and ISS trauma scoring system for the prediction of mortality among multiple trauma patients. Annals of Medicine and Surgery [Internet]. 2022;76(March):103536. https://doi.org/10.1016/j.amsu.2022.103536

Hakimzadeh Z, Vahdati SS, Ala A, Rahmani F, Ghafouri RR, Jaberinezhad M. The predictive value of the Kampala Trauma Score (KTS) in the outcome of multi-traumatic patients compared to the estimated Injury Severity Score (eISS). BMC Emergency Medicine. 2024;24(1):1–10. https://doi.org/10.1186/s12873-024-00989-w

Damulira J, Muhumuza J, Kabuye U, Ssebaggala G, Wilson ML, Bärnighausen T, et al. New Trauma Score versus Kampala Trauma Score II in predicting mortality following road traffic crash: a prospective multi-center cohort study. BMC Emergency Medicine. 2024;24(1):1–10. https://doi.org/10.1186/s12873-024-01048-0

Usman N, Ruchimat T, Rahmawan A. Accuracy of Kampala Trauma Score as a Predictor in Assessing the Prognostic Value of Multiple Trauma. Majalah Kedokteran Bandung. 2023;55(4):247–53. https://doi.org/10.15395/mkb.v55n4.3080

Patel R, Ghag GS, Iyer S, Nandu VV. The Revised Trauma Score: A Better Early Predictor for Survival of Head Trauma Patients than the Glasgow Coma Scale-Age-Pressure Score. Journal Acute Care Surgery. 2024;14(2):52–8. https://doi.org/10.17479/jacs.2024.14.2.52

Pérez-Casal M, Thompson V, Downey C, Welters I, Wyncoll D, Thachil J, et al. The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis. Critical Care. 2021;15(4):1–11. https://doi.org/10.1186/cc10356

Javeed F, Rehman L, Masroor M, Khan M. The Prediction of Outcomes in Patients Admitted With Traumatic Brain Injury Using the Rotterdam Score. Cureus. 2022;0(9):25–30. https://doi.org/10.7759/cureus.29787

Demlie TA, Alemu MT, Messelu MA, Wagnew F, Mekonen EG. Incidence and predictors of mortality among traumatic brain injury patients admitted to Amhara region Comprehensive Specialized Hospitals, northwest Ethiopia, 2022. BMC Emergency Medicine. 2023;23(1):1–11. https://doi.org/10.1186/s12873-023-00823-9

Wikantama A, Sudadi, Widyastuti Y. Sistem Revised Trauma Score (Rts) Sebagai Prediktor Mortalitas Pasien Cedera Otak Traumatik Di Rsup Dr. Sardjito. Jurnal Komplikasi Anestesi. 2020;7(3):13–21. https://doi.org/10.22146/jka.v7i3.7469

Yadollahi M, Kashkooe A, Rezaiee R, Jamali K, Niakan MH. A Comparative Study of Injury Severity Scales as Predictors of Mortality in Trauma Patients: Which Scale Is the Best? Bulletin of Emergency and Trauma. 2020;8(1):27–33. https://doi.org/10.29252/beat-080105

Knapp J, Doppmann P, Huber M, Meuli L, Albrecht R, Sollid S, et al. Pre-hospital endotracheal intubation in severe traumatic brain injury: ventilation targets and mortality—a retrospective analysis of 308 patients. Scandinavian Journal of Trauma Resuscitation and Emergergency Medicine [Internet]. 2023;31(1):1–9. https://doi.org/10.1186/s13049-023-01115-8

MacLeod JBA, Kobusingye O, Frost C, Lett R, Kirya F, Shulman C. A Comparison of the Kampala Trauma Score (KTS) with the Revised Trauma Score (RTS), Injury Severity Score (ISS) and the TRISS Method in a Ugandan Trauma Registry: Is Equal Performance Achieved with Fewer Resources? European Journal Trauma. 2023;29(6):392–8. https://doi.org/10.1007/s00068-003-1277-5

Khan M, O’Keeffe, TereKhan, M., O’Keeffe, T., Jehan, F. S., Kulvatunyou, N., Kattaa, A., Gries, L., Tang, A., & Joseph, B. (2017). The Impact of GCS-Age Prognosis (GAP) Score on Geriatric TBI Outcomes. Journal of Surgery Research. 2017;2(16):216. https://doi.org/10.1016/j.jss.2017.04.026

Driessen MLS, van Klaveren D, de Jongh MAC, Leenen LPH, Sturms LM. Modification of the TRISS: simple and practical mortality prediction after trauma in an all-inclusive registry. European Journal Trauma Emergergency Surgery [Internet]. 2022;48(5):3949–59. https://doi.org/10.1007/s00068-022-01913-2

Velonas G, Mantas D, Kassianidis G, Poulianidou V, Patrani M. Evaluation of the Trauma and Injury Severity Score ( TRISS ) Performance in Intensive Care Trauma Patients : A Systematic Review and Meta- Analysis. Cureus. 2025;17(10). https://doi.org/10.7759/cureus.95476

Kim DK, Lee DH, Lee BK, Cho YS, Ryu SJ, Jung YH, et al. Performance of modified early warning score (Mews) for predicting in-hospital mortality in traumatic brain injury patients. Journal of Clinic Medicine. 2021;10(9):0–9. https://doi.org/ 10.3390/jcm10091915

Komboz F, Chehade HD, Al Saffar B, Mielke D, Rohde V, Abboud T. Assessing outcomes in traumatic brain injury: Helsinki score versus Glasgow coma scale. European Journal of Trauma and Emergency Surgery. 2024; https://doi.org/ 10.1007/s00068-024-02604-w

Cho M, Lee S, Kim HJ. Assessing the predictive power of the GAP score on mechanical complications: a comprehensive systematic review and meta-analysis. European Spine Journal [Internet]. 2024;33(4):1311–9. https://doi.org/10.1007/s00586-024-08135-7

Jokšić-Mazinjanin R, Marić N, Đuričin A, Gojković Z, Vasović V, Rakić G, et al. Prehospital Trauma Scoring Systems for Evaluation of Trauma Severity and Prediction of Outcomes. Medicina. 2023;59(5):1–11. https://doi.org/10.3390/medicina59050952

Shafiei M, Maleki S, Nasr Isfahani M, Amin A. Predictive power of the eTBI score for 30 day outcome in elderly patients with traumatic brain Injury. Scientific Reports. 2024;14(1):25862. https://doi.org/10.1038/s41598-024-77561-w

Naghavi M, Ong KL, Aali A, Ababneh HS, Abate YH, Abbafati C, et al. Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet. 2024;403(10440):2100–32.

Ariaka H, Kiryabwire J, Hussein S, Ogwal A, Nkonge E, Oyania F. A Comparison of the Predictive Value of the Glasgow Coma Scale and the Kampala Trauma Score for Mortality and Length of Hospital Stay in Head Injury Patients at a Tertiary Hospital in Uganda: A Diagnostic Prospective Study. Surgery Research Practice. 2020;2(1):1–9. https://doi.org/10.1155/2020/1362741

Chokotho L, Croke K, Mohammed M, Mulwafu W, Bertfelt J, Karpe S, et al. Epidemiology of adult trauma injuries in Malawi: results from a multisite trauma registry. Injury Epidemiology [Internet]. 2022;9(1):1–10. https://doi.org/10.1186/s40621-022-00379-5

Haac B, Varela C, Geyer A, Cairns B, Charles A. The Utility of the Kampala Trauma Score as a Triage Tool in a Sub-Saharan African Trauma Cohort. world Journal Surgery. 2020;39(2):356–62. https://doi.org/10.1007/s00268-014-2830-6

Rosenkrantz L, Schuurman N, Hameed M, Boniface R, Lett R. The Kampala Trauma Score: A 20-year track record. Journal of Trauma and Acute Care Surgery [Internet]. 2022;92(6):132–8. https://doi.org/10.1097/TA.0000000000003567

J. L. Jenkins et al. Revised Trauma Score and its role in trauma management protocols. International Journal of Trauma Nursing. 2022;58(8.5.2017):2003–5. https://doi.org/10.1016/j.ijtn.2022.03.001

Silva LAGPD, Lopes VJ, Merces NNA. Symptom management theory applied to nursing care: scoping review. Revista brasileira de enfermagem. 2021;74(3):e20201004. https://doi.org/10.1590/0034-7167-2020-1004

Moorthy DSRK, Rajesh K, Priya S, Abhinov T, Prasad KD. Prediction of Outcome Based on Trauma and Injury Severity Score , IMPACT and CRASH Prognostic Models in Moderate ‑ to ‑ Severe Traumatic Brain Injury in the Elderly. Asian Journal of Neurosurgery. 2021;16(3):500. https://doi.org/10.4103/ajns.AJNS_512_20

Zhou Y, Zhou L, Chen X. * The Role of Integrated Nursing Interventions in Traumatic Brain Injury Management in the Emergency Department: A Retrospective Study. Therapeutics and Clinical Risk Management. 2025;21:769-780. https://doi.org/10.2147/TCRM.S512673

Huang DH, Xie YC, Zhang CL. Effects of comprehensive nursing intervention on pressure ulcer after traumatic brain injury surgery: A meta-analysis. International Wound Journal. 2023;21(4):1-9. https://doi.org/10.111/iwj.14494




DOI: http://dx.doi.org/10.21927/jnki.2025.13(4).539-557

Refbacks

  • There are currently no refbacks.


Jurnal Ners dan Kebidanan Indonesia (JNKI) indexed by:

      

Lisensi Creative Commons

  View My Stats