A prospective observational study to evaluate the association of various maternal risk factors with increasing incidence of term neonatal jaundice
Abstract
Background: In our setting majority of the mothers were discharged on postnatal day 3.but over the past few years the NICU admissions also increased prolonging the hospital stay of mothers leading to increase in the hospital acquired infections for both mother and baby. This study was developed in this context.
Objectives: The present study was performed with the purpose of establishing the incidence of neonatal jaundice in term neonates and the role of the various maternal factors being responsible for exaggerated physiological hyperbilirubinemia in term neonates.
Methods: Using the NICE gestational age-based phototherapy chart, this study analysed serum bilirubin of the term newborns on their day 2 of life. Total 155 antenatal mothers were taken for study. Associations between maternal risk factors and neonatal jaundice and comparing risk factors in early-term, term, and late-term newborns were assessed using chi-squared or Fisher’s exact tests
Results: Incidence of neonatal jaundice is 58.1% in this study. Age, BMI, weight gain of the mother had no significant correlation with neonatal jaundice. Blood group incompatibility had a positive corelation (P=.001) Gestational age at the time of delivery determines the neonatal outcome. (P=.001). As gestation advances the neonatal outcomes are better. Hyperbilirubinemia incidence more at 37 -38 weeks when compared to 39 weeks. Maternal comorbidities, amniotic fluid volume changes, mode of delivery didn’t have statistical significance. when new-born factors are considered birth weight, gender growth problems, blood group has no statistical significance whereas dehydration proved to be significant (P=.001). meconium-stained amniotic fluid[P-0.034] were found to be associated with the development of neonatal jaundice.
Conclusions: The prevalence of jaundice is higher in this study. maternal and foetal blood group incompatibility, gestational age at delivery, meconium-stained amniotic fluid, neonatal dehydration was found to be associated with the development of neonatal jaundice.
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Brits H, Adendorff J, Huisamen D, et al. The prevalence of neonatal jaundice and risk factors in healthy term neonates at National District Hospital in Bloemfontein. African Journal of Primary Health Care & Family Medicine. 2018;10(1): e1-e6. Published 2018 Apr 12. https://doi.org/10.4102/phcfm.v10i1.1582
Khan RS, Houlihan DD, Newsome PN. Investigating jaundice. Medicine.2015;43(10):573–576. https://doi.org/10.1016/j.mpmed.2015.07.009
National Institute for Health and Care Excellence. Neonatal jaundice. Clinical guideline 98. London: Royal College of Obstetricians and Gynaecologists; 2010 [cited 2016 Jun 15]. Available from: https://www.nice.org.uk/guidance/cg98/evidence/full-guideline-pdf-245411821
Lake EA, Abera GB, Azeze GA, Gebeyew NA, Demissie BW. Magnitude of neonatal jaundice and its associated factor in neonatal intensive care units of Mekelle city public hospitals, Northern Ethiopia. International Journal of Paediatrics. 2019 Apr 10;2019. https://doi.org/10.1155/2019/1054943
Yigit S, Gursoy T, Kanra T, Aydin M, Erdem G, Tekinalp G, Yurdakok MU. Whole blood versus red cells and plasma for exchange transfusion in ABO haemolytic disease. Transfusion medicine. 2005 Aug;15(4):313-8. https://doi.org/10.1111/j.0958-7578.2005.00593.x
Hedderson MM, Weiss NS, Sacks DA, Pettitt DJ, Selby JV, Quesenberry CP, Ferrara A. Pregnancy weight gain and risk of neonatal complications: macrosomia, hypoglycemia, and hyperbilirubinemia. Obstetrics & Gynaecology. 2006 Nov 1;108(5):1153-61 https://doi.org/10.1097/01.aog.0000242568.75785.68
Sutcuoglu S, Dursun S, Halicioglu O, Ozturk C, Akman S, Yaprak I, Ozer E. Evaluation of maternal knowledge level about neonatal jaundice. The Journal of Maternal-Fetal & Neonatal Medicine. 2012 Aug 1;25(8):1387-9 https://doi.org/10.3109/14767058.2011.636095
Arad I, Fainmesser P, Birkenfeld A, Gulaiev B, Sadovsky E. Vacuum extraction and neonatal jaundice.
Boskabadi H, Rakhshanizadeh F, Zakerihamidi M. Evaluation of maternal risk factors in neonatal hyperbilirubinemia. Archives of Iranian Medicine. 2020 Feb 1;23(2):128-40.
Qadir SY, Yasmin T, Fatima I. Maternal and foetal outcome in gestational diabetes. Journal of Ayub Medical College Abbottabad. 2012 Dec 1;24(3-4):17-20
Khorsheed RM. Review of Patients With Abo Incompatibilty In Healthy Neonatal Jaundice In Kirkuk. Kirkuk Journal of Medical Sciences. 2022 May 1;10(1):44-63 https://doi.org/10.32894/kjms.2022.174185
Devi AN, Pathri M, Tammala S. Relationship between maternal abo blood group and rh typing with maternal and perinatal outcome. EUREKA: Health Sciences. 2022 Nov 30(6):44-54 https://doi.org/10.21303/2504-5679.2022.002723
Gartner LM. Journal of perinatology: official journal of the California Perinatal Association. 2001;21: S25–39.
Anne RP, Rahiman EA, Dudeja S, Kumar A. Diagnostic accuracy of cord bilirubin to predict the need for phototherapy in healthy neonates> 35 weeks gestational age-A systematic review and meta-analysis. Journal of Clinical and Experimental Hepatology. 2022 Nov 26. https://doi.org/10.1016/j.jceh.2022.11.011
Thomas M, Greaves RF, Tingay DG, Loh TP, Ignjatovic V, Newall F, Oeum M, Tran MT, Rajapaksa AE. Current and emerging technologies for the timely screening and diagnosis of neonatal jaundice. Critical Reviews in Clinical Laboratory Sciences. 2022 Feb 18:1-21. https://doi.org/10.1080/10408363.2022.2038074
Ghavami S, Thirumoorthi V. Assessment of Various Maternal Risk Factors and Treatment Approaches for Neonatal Jaundice in a Tertiary Care Hospital. International Journal of Pharmaceutical Investigation. 2022 Apr 1;12(2). https://doi.org/10.5530/ijpi.2022.2.42
Kuzniewicz MW, Wickremasinghe AC, Wu YW, McCulloch CE, Walsh EM, Wi S, Newman TB. Incidence, etiology, and outcomes of hazardous hyperbilirubinemia in newborns. Pediatrics. 2014 Sep;134(3):504-9 https://doi.org/10.1542/peds.2014-0987
Guedalia J, Farkash R, Wasserteil N, Kasirer Y, Rottenstreich M, Unger R, Granovsky SG. Primary risk stratification for neonatal jaundice among term neonates using machine learning algorithm. Early Human Development. 2022 Feb 1;165:105538. https://doi.org/10.1016/j.earlhumdev.2022.105538
Kaur N, Dhillon GK, Sasidharan S, Dhillon HS. Maternal and neonatal risk factors for neonatal jaundice and readmission–An Indian perspective. Acta Medica International. 2021 Jan 1;8(1):44 http://dx.doi.org/10.4103/amit.amit_62_21
Sutcuoglu S, Dursun S, Halicioglu O, Ozturk C, Akman S, Yaprak I, Ozer E. Evaluation of maternal knowledge level about neonatal jaundice. The Journal of Maternal-Fetal & Neonatal Medicine. 2012 Aug 1;25(8):1387-9. https://doi.org/10.3109/14767058.2011.636095
Maastrup R, Hannula L, Hansen MN, Ezeonodo A, Haiek LN. The Baby‐friendly Hospital Initiative for neonatal wards. A mini review. Acta Paediatrica. 2022 Apr;111(4):750-5. https://doi.org/10.1111/apa.16230
Mazahir FA, Chiken SS, Malik EM, Nair A. 765 Exclusive breastfeeding practices in babies admitted with neonatal jaundice at latifa women and children hospital-Dubai, United Arab Emirates.
Aminatussyadiah A. The Correlation Between Birth Weight and Incidence of Neonatal Jaundice at Rskia Sadewa Babarsari Sleman in 2014.
Kuzniewicz MW, Park J, Niki H, Walsh EM, McCulloch CE, Newman TB. Predicting the Need for Phototherapy After Discharge. Pediatrics. 2021 May 1;147(5). https://doi.org/10.1542/peds.2020-019778
Tartaglia KM, Campbell J, Shaniuk P, McClead RE. A quality project to improve compliance with AAP guidelines for inpatient management of neonatal hyperbilirubinemia. Hospital Pediatrics. 2013 Jul 1;3(3):251-7. https://doi.org/10.1542/hpeds.2012-0103
Vayssière C, Beucher G, Dupuis O, et al. Instrumental delivery: clinical practice guidelines from the French College of Gynaecologists and Obstetricians. Eur J Obstet Gynecol Reprod Biol. 2011;159(1):43-48. doi:10.1016/j.ejogrb.2011.06.043 https://doi.org/10.1016/j.ejogrb.2011.06.043
DOI: http://dx.doi.org/10.21927/jnki.2023.11(4).392-404
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