PENINGKATAN KADAR INSULIN TIKUS WISTAR (Rattus norvegicus) JANTAN YANG DIINDUKSI STREPTOZOTOSIN AKIBAT PEMBERIAN EKSTRAK ETANOL BATANG BROTOWALI (Tinospora crispa L.)

Ayu - Ashari, Eva Nurinda, Annisa Fatmawati

Abstract


Brotowali stems (Tinospora crispa L.) contain flavonoids which act as antioxidants and are expected to have the potential to reduce blood glucose levels and increase insulin levels in mice due to STZ induction. The purpose of this study was to determine the effect of brotowali stem ethanol extract (EEBB) on insulin levels in STZ-induced male Wistar rats. Measurement of mouse insulin levels using the mouse insulin ELISA kit method. The results showed that the ethanol extract of brotowali rods at a dose of 450 mg / kgBW rats were significantly different (<0.05) between the hyperglycemic control group and the EEBB treatment group showing an increase in the mean insulin levels of the rats after being given EEBB for 10 days. Brotowali stems can be used for the treatment of natural ingredients with flavonoid content.

 


Keywords


Brotowali stem, Diabetes mellitus, insulin levels, Tinospora crispa L., STZ

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DOI: http://dx.doi.org/10.21927/inpharnmed.v5i1.1653

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