Giving green grass jelly for mda (malondialdehyde) level in pregnant women with hypertension

Meika Jaya Rochkmana, Ari Suwondo, Sulistyani Sulistyani



Background: Hypertension is a disease that often occurs during pregnancy. Many factors influence the occurrence of hypertension, one of which is oxidative stress. Oxidative stress has an important role in the pathogenesis of hypertension in pregnancy and may be a pathway that can lead to tissue damage. Oxidative stress can stimulate the release of cytokines, antiangiogenic, microparticles and other important molecules in hypertension. Oxidative stress is caused by an imbalance of prooxidants and antioxidants. So we need antioxidants that can suppress oxidative stress in pregnant women with hypertension. Green grass jelly contains alkaloids and flavonoids. Where flavonoids can act as antioxidants and anti-inflammatory. Flavonoids can reduce arterial stiffness making Reactive Oxygen Species (ROS) decrease so that fat peroxide decreases and is followed by decreased oxidative stress, then endothelial function will increase and vasodilation occurs. Malondialdehyde (MDA) is an aldehyde marker compound that is important to see lipid peroxidation and oxidative damage caused by Reactive Oxygen Species (ROS).

Objectives: To prove that giving green grass jelly has an effect on reducing oxidative stress in pregnant women.

Methods: This study used a quasy experiment with a pretest and posttest control design. A sample of 30 was divided into 2 groups. The group with green grass jelly intervention was 15 people who were given green grass jelly as much as 150 grams per day for 14 days. The second group as many as 15 people as the control group.

Results: The green grass jelly intervention group had a significant difference with p-value <0.05. For malondialdehyde results in the control group there was no change in p-value > 0.05. The mean decrease in malondialdehyde levels in the control group was 0.0560 nmol/ml while the average decrease in malondialdehyde in the intervention group was 1.3133 nmol/ml.

Conclusions: Green grass jelly is effective and significant for reducing malondialdehyde levels in pregnant women with mild hypertension.


green grass jelly; MDA (malondialdhyde); pregnant hypertension

Full Text:



Sarker Shamima Ahmed , Nazma Sultana, Most Luthy Begum, Lobaba Sultana Lima MFA and, Hosen MK. Pregnancy Induced Hypertension and Associated Factors among Pregnant Women. J Gynecol Womens Heal [Internet]. 2017;3(5). Available from:

Kattah AG, Garovic VD. The Management of Hypertension in Pregnancy. 2014;20(3):229–39.

Paarul Prinja Catherine Nelson-Piercy. Hypertension in pregnancy. J mpmed [Internet]. 2018;76(3):254–63. Available from: 2018.09.010

Dinas Kesehatan Provinsi Jawa Tengah. Profil Kesehatan Provinsi Jawa Tengah Tahun 2017.

2016 DKKM. Profil Kesehatan Kabupaten Magelang Tahun 2016. 2016 p. 1–147.

El-Sayed AAF. Preeclampsia: A review of the pathogenesis and possible management strategies based on its pathophysiological derangements. Taiwan J Obstet Gynecol. 2017;56(5):593–8.

Sohlberg S, Mulic-Lutvica A, Lindgren P, Ortiz-Nieto F, Wikström AK, Wikström J. Placental perfusion in normal pregnancy and early and late preeclampsia: A magnetic resonance imaging study. Placenta [Internet]. 2014;35(3):202–6. Available from:

Yoshida A, Watanabe K, Iwasaki A, Kimura C, Matsushita H, Wakatsuki A. Placental oxidative stress and maternal endothelial function in pregnant women with normotensive fetal growth restriction. J Matern Neonatal Med [Internet]. 2018;31(8):1051–7. Available from: 06510

Nasri H, Baradaran A, Rafieian-Kopaei M. Oxidative stress and hypertension: Possibility of hypertension therapy with antioxidants. J Res Med Sci. 2014;19(4):358–67.

Dsouza V, Rani A, Patil V, Pisal H, Randhir K, Mehendale S, et al. Increased oxidative stress from early pregnancy in women who develop preeclampsia. Clin Exp Hypertens. 2016;38(2):225–32.

Schoots MH, Gordijn SJ, Scherjon SA, van Goor H, Hillebrands JL. Oxidative stress in placental pathology. Placenta [Internet]. 2018;69:153–61. Available from:

Gathiram P, Moodley J. Review Articles Pre-eclampsia : its pathogenesis and pathophysiolgy. Cardiovasc J Afr. 2016;27(2):71–8.

Fitton CA, Steiner MFC, Aucott L, Pell JP, Mackay DF, Fleming M, et al. In-utero exposure to antihypertensivemedication and neonatal andchild health outcomes: a systematic review. J Hypertens. 2017;35(11):2123–37.

Van Gelder MMHJ, Van Bennekom CM, Louik C, Werler MM, Roeleveld N, Mitchell AA. Maternal hypertensive disorders, antihypertensive medication use, and the risk of birth defects: A case-control study. BJOG An Int J Obstet Gynaecol. 2015;122(7):1002–9.

Kusmardiyani S, Insanu M, Asyhar M Al. Effect A Glycosidic Flavonol Isolated from Green Grass Jelly (Cyclea Barbata Miers) Leaves. Procedia Chem [Internet]. 2014;13:194–7. Available from: S18766


Rizki PR, Jayanti RD, Widyaningsih TD. Effect of Herbal Tea Based Green Grass Leaf for the Level of Blood and Lipid Profile of Rat Wistar Hiperglikemia. J Pangan dan Agroindustri. 2015;3(3):803–14.

Sundar Fitriana, Leily Amalia KRE. Green grass jelly drink (Premna oblongifolia Merr.) can reduce blood pressure of adult women suffered from mild and moderate hypertension. J Gizi Pangan. 2014;9(November):203–10.

Genc H, Uzun H, Benian A, Simsek G, Gelisgen R, Madazli R, et al. Evaluation of oxidative stress markers in first trimester for assessment of preeclampsia risk. Arch Gynecol Obstet. 2011;284(6):1367–73.

Trejo-Moreno C, Méndez-Martínez M, Zamilpa A, Jiménez-Ferrer E, Perez-Garcia MD, Medina-Campos ON, et al. Cucumis sativus aqueous fraction inhibits angiotensin II-induced inflammation and oxidative stress in vitro. Nutrients. 2018;10(3).

Cindrova-Davies T. Gabor Than Award Lecture 2008 : Pre-eclampsia – From Placental Oxidative Stress to Maternal Endothelial Dysfunction. Placenta [Internet]. 2009;30:55–65. Available from:

Shu W, Li H, Gong H, Zhang M, Niu X, Ma Y, et al. Evaluation of blood vessel injury, oxidative stress and circulating inflammatory factors in an l-name-induced preeclampsia-like rat model. Exp Ther Med. 2018;16(2):585–94.

Bhale D, Mahat R. Study of Oxidative Stress in Patients of Pregnancy Induced Hypertension. Int J Recent Trends Sci Technol. 2013;9(1):155–6.

Yeni C, Mose J, Ruslami R, Maskoen A, Fauziah P. Effect of curcumin in decreasing MDA level in pre-eclampsia-induced human umbilical vein endothelial cell (HUVEC). Ultrasound Obstet Gynecol [Internet]. 2017;50(October 2018):333–333. Available from:

Martin Lajous, Emilie Rossignol, Guy Fagherazzi, Florence Perquier, Augustin Scalbert, Franc¸oise Clavel-Chapelon and M-CB-R. Flavonoid intake and incident hypertension in women. Am J Clin Nutr [Internet]. 2016;103(4):1091–8. Available from:



  • There are currently no refbacks.

Jurnal Ners dan Kebidanan Indonesia (JNKI) indexed by:


Lisensi Creative Commons

  View My Stats