Tren Global Penelitian Toll-like receptor 4 pada Penyakit Kardiovaskular: Analisis Bibliometrik 2017-2025

Danang Amukti; Daru Estiningsih; Tetie Herlina; Nurul Kusumawardani; Ade Puspitasari; Latifa Amalia; Ifa Aris Suminingtyas; Eva Nurinda; Sundari Desi Nuryanti; Ari Susiana Wulandari; Ria Indah Pratami

doi:10.21927/inpharnmed.v9i1.5989

Tren Global Penelitian Toll-like receptor 4 pada Penyakit Kardiovaskular: Analisis Bibliometrik 2017-2025

Danang Amukti, Daru Estiningsih, Tetie Herlina, Nurul Kusumawardani, Ade Puspitasari, Latifa Amalia, Ifa Aris Suminingtyas, Eva Nurinda, Sundari Desi Nuryanti, Ari Susiana Wulandari, Ria Indah Pratami

Abstract

Toll-like receptor 4 (TLR4) memiliki peran penting dalam patogenesis penyakit kardiovaskular (PKV) melalui mediasi respons inflamasi. Meskipun peran molekul ini semakin dikenal, belum ada kajian bibliometrik komprehensif yang mengulas tren global publikasi terkait TLR4 dalam konteks PKV secara sistematis.Tujuan penelitian ini bertujuan untuk menganalisis dinamika publikasi ilmiah global tentang TLR4 pada PKV dalam kurun waktu 2017–2025 menggunakan pendekatan bibliometrik. Data dikumpulkan dari database Scopus dengan kata kunci “Toll-like receptor 4” dan “cardiovascular”, difilter berdasarkan judul, abstrak, dan kata kunci, serta dibatasi pada dokumen berbahasa Inggris. Sebanyak 1.939 dokumen dianalisis menggunakan perangkat lunak Bibliometrix (R) dan VOSviewer untuk mengevaluasi tren publikasi, produktivitas penulis, kontribusi negara dan institusi, pemetaan kata kunci, dan artikel yang paling berpengaruh. Tiongkok mendominasi jumlah publikasi (592 dokumen), sementara Amerika Serikat mencatat pengaruh ilmiah tertinggi melalui kolaborasi internasional dan jumlah sitasi. Penulis paling produktif adalah Li Y dan Wang Y, sedangkan institusi teratas adalah Mashhad University dan Capital Medical University. Peta kata kunci menunjukkan empat klaster utama: inflamasi-imunitas, stres oksidatif-apoptosis, metabolisme, dan model hewan. Artikel paling disitasi berasal dari jurnal bereputasi tinggi seperti Signal Transduction and Targeted Therapy dan Nature Reviews Rheumatology. TLR4 merupakan target utama dalam penelitian multidisipliner dan translasi pada penyakit kardiovaskular. Hasil studi ini dapat menjadi acuan penting untuk perumusan strategi riset lanjutan dan kolaborasi global yang lebih terarah.

Keywords

bibliometrik; global; kardiovaskular; toll-like receptor 4

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DOI: http://dx.doi.org/10.21927/inpharnmed.v9i1.5989