Efektivitas Tepung Porang (Amorphophallus oncophyllus) Dalam Menurunkan Kadar Glukosa Darah dan Meningkatkan Berat Badan Pada Tikus Diabetes yang Diinduksi Streptozotocin
DOI:
https://doi.org/10.21927/inpharnmed.v9i2.6568Keywords:
Tepung porang, Amorphophallus Oncophyllus, glukomanan, antioksidan, diabetes mellitusAbstract
Prevalensi diabetes mellitus tipe 2 meningkat secara signifikan, sehingga diperlukan intervensi berbasis pangan fungsional. Porang (Amorphophallus oncophyllus) mengandung glukomanan yang berpotensi sebagai terapi adjuvan diabetes. Mengetahui efek pemberian tepung porang terhadap kadar glukosa darah dan berat badan tikus diabetes yang diinduksi streptozotocin (STZ). Penelitian eksperimental dengan desain *pretest-posttest randomized controlled group design* menggunakan 30 ekor tikus jantan galur Wistar. Tikus dibagi menjadi 5 kelompok: normal, kontrol negatif, kontrol positif (glibenklamid 0,1 mg/kgBB), porang dosis 40 mg/kgBB, dan porang dosis 400 mg/kgBB. Diabetes diinduksi dengan STZ 45 mg/kgBB intraperitoneal. Pengukuran glukosa darah dilakukan hari ke-0, 7, dan 14, sedangkan berat badan diukur hari ke-0, 3, 7, 10, dan 14. Data dianalisis menggunakan ANOVA satu arah dilanjutkan uji LSD (p<0,05). Kelompok porang dosis 400 mg/kgBB menunjukkan penurunan glukosa darah yang signifikan dari 386,00±24,99 mg/dL menjadi 101,00±21,60 mg/dL (p<0,05), serta peningkatan berat badan dari 130,00±3,24 g menjadi 147,25±12,12 g. Hasil ini setara dengan kelompok glibenklamid dan lebih baik dibandingkan kelompok porang dosis 40 mg/kgBB. Tepung porang dosis 400 mg/kgBB efektif menurunkan glukosa darah dan meningkatkan berat badan pada tikus diabetes yang diinduksi STZ.
References
Badan Penelitian dan Pengembangan Kesehatan. Riset Kesehatan Dasar (RISKESDAS) 2013. Jakarta: Kementerian Kesehatan Republik Indonesia; 2013..
Dinas Kesehatan Bantul. Profil Kesehatan Dinas Kabupaten Bantul. Profil Kesehatan. 2018.
Zhou X, Siegel KR, Ng BP, Jawanda S, Proia KK, Zhang X, dkk. Cost-effectiveness of Diabetes Prevention Interventions Targeting High-risk Individuals and Whole Populations: A Systematic Review. Diabetes Care. 1 Juli 2020;43(7):1593–616. https://doi.org/10.2337/dci20-0018
Gerontiti E, Shalit A, Stefanaki K, Kazakou P, Karagiannakis DS, Peppa M, dkk. The role of low glycemic index and load diets in medical nutrition therapy for type 2 diabetes: an update. Hormones. 16 Desember 2024;23(4):655–65. https://doi.org/10.1007/s42000-024-00566-7
Chiavaroli L, Lee D, Ahmed A, Cheung A, Khan T, Mejia SB, dkk. Low Glycemic Index/Load Dietary Patterns and Glycemia and Cardiometabolic Risk Factors in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Current Developments in Nutrition Journal. Juni 2021;5:1018. https://doi.org/10.1093/cdn/nzab053_011
Nurlela N, Ariesta N, Santosa E, Mulandri T. Physicochemical properties of glucomannan isolated from fresh tubers of Amorphophallus muelleri Blume by a multilevel extraction method. Food Research International Jurnal. 18 Agustus 2022;6(4):345–53. https://doi.org/10.26656/fr.2017.6(4).580
Young A, Novita BD, Ricardo E, Dewi IGAPD, Amadeo J, Dewi S, dkk. Hypoglycemic, Anti-Inflammatory Effect Of Porang (Amorphophallus Onchopyllus) On Alloxan-Induced Diabetic Rats. Jurnal Widya Medika. April 2023;9(1):13–25.
Young A, Novita BD, Ricardo E, Dewi IGAPD, Amadeo J, Dewi S, dkk. Hypoglycemic, Anti-Inflammatory Effect Of Porang (Amorphophallus Onchopyllus) On Alloxan-Induced Diabetic Rats. Jurnal Widya Medika. April 2023;9(1):13–25.
Aprilia V, Murdiati A, Hastuti P, Harmayani E. Carboxymethylation of Glucomannan from Porang Tuber (Amorphophallus oncophyllus) and the Physicochemical Properties of the Product. Pakistan Journal of Nutrition. 15 Oktober 2017;16(11):835–42. https://doi.org/10.3923/pjn.2017.835.842
Yoshida A, Kimura T, Tsunekawa K, Araki O, Ushiki K, Ishigaki H, dkk. Glucomannan Inhibits Rice Gruel-Induced Increases in Plasma Glucose and Insulin Levels. Annals of Nutrition and Metabolism2020;76(4):259–67. https://doi.org/10.1159/000508674
Okoduwa SIR, Umar IA, James DB, Inuwa HM. Appropriate Insulin Level in Selecting Fortified Diet-Fed, Streptozotocin-Treated Rat Model of Type 2 Diabetes for Anti-Diabetic Studies. PLoS One. 27 Januari 2017;12(1):e0170971.
Arunachalam K, Sasidharan SP. Animal Experiments of Anti-Diabetic Activities. Dalam 2021. hlm. 191–200.
William NR. Pharmacological Evaluation of Novel Antidiabetic Agents Targeting GLP-1 Receptors. Journal of Pharmacology, Genetics and Molecular Biology. 4 Agustus 2025;202–12. https://doi.org/10.64062/JPGMB.Vol1.Issue4.17
Raza H, John A. Streptozotocin-Induced Cytotoxicity, Oxidative Stress and Mitochondrial Dysfunction in Human Hepatoma HepG2 Cells. International Journal of Molecular Sciences. 11 Mei 2012;13(5):5751–67. https://doi.org/10.3390/ijms13055751
Kahraman S, Aydin C, Elpek GO, Dirice E, Sanlioglu AD. Diabetes-Resistant NOR Mice Are More Severely Affected by Streptozotocin Compared to the Diabetes- Prone NOD Mice: Correlations with Liver and Kidney GLUT2 Expressions. Journal of Diabetes Research. 2015;2015:1–8. https://doi.org/10.1155/2015/450128
Aprilia V, Estiningsih D, Fauzi R, Nurinda E. Pengaruh beberapa variasi tepung porang terhadap kadar glukosa darah tikus Wistar yang diiunduksi DM. Yogyakarta; 2019.
Chairiyah N, Harijati N, Mastuti R. Chemical Compounds & Crystal Development of Porang Tuber (Chairiyah, et al). Journal of Experimental Life Sciences. 2023;13(1):2023. https://doi.org/10.21776/ub.jels.2023.013.01.01
A’yun RQ, Hasanah U, Hadi H, Mustofa M, Nurinda E, Kurniasari Y, dkk. Acute toxicity study of porang (Amorphophallus oncophyllus) flour macerated with strobilanthes crispus in wistar rats. Open Access Macedonian Journal of Medical Sciences. 2021;9:976–81. https://doi.org/10.3889/oamjms.2021.6813
Rosida DF, Sarofa U, Aliffauziah D. Characteristics of non-gluten noodles from modified cocoyam (Xanthosoma sagittifolium) and porang (Amorphophallus oncophyllus). Italian Journal of Food Science. 2022;34(1):13–23. https://doi.org/10.15586/ijfs.v34i1.2080
Gauthier EL. Streptozotocin: Uses, mechanism of action and side effects. Streptozotocin: Uses, Mechanism of Action and Side Effects. 2014.
Ghorbani A. Mechanisms of antidiabetic effects of flavonoid rutin. Biomedicine and Pharmacotherapy. 2017.
Rizka Karima BERS. Mechanism of Action of Glucomannan as a Potential Therapeutic Agent for Type 2 Diabetes Mellitus Based on Network Pharmacology
and Molecular Docking Simulation. Tropical Journal of Natural Product Research. 31 Desember 2023;7(12).
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